منابع مشابه
IgG rheumatoid factor synthesis in synovial fluid.
Sir: Winchester et al two decades ago proposed that IgG rheumatoid factor (RF) could be locally produced in plasma cells that line the synovium.' We conducted a short study looking at paired samples of synovial fluid (from the knee joint) and serum from patients with definite rheumatoid arthritis to determine if the production of IgG RF is localised in the synovial fluid. Thirty six serum sampl...
متن کاملAntigammaglobulin (rheumatoid factor) activity of human IgG subclasses.
A sensitive radioimmunoassay has been applied to the study of rheumatoid factor activity of IgM and IgG subclasses in serum and synovial fluid of patients with rheumatoid arthritis. Although rheumatoid factor activity was found in all four subclasses, its distribution was not the same as that of the total subclasses in normal sera. Results are discussed in relation to the possible clinical valu...
متن کاملDisease activity and joint damage progression in early rheumatoid arthritis: relation to IgG, IgA, and IgM rheumatoid factor.
The clinical and biochemical correlations with joint damage progression over two years in a consecutive group of 68 patients with rheumatoid arthritis with disease duration of less than two years are reported. Joint damage was assessed with Larsen's severity scale and a measure of change in progression rate constructed. Initial haemoglobin concentration, Ritchie index, and Waaler-Rose titre in ...
متن کاملComplement mediated inhibition of immune precipitation in rheumatoid arthritis: studies on interaction of heat aggregated IgG with IgM rheumatoid factor.
Serum samples from patients with seropositive rheumatoid arthritis contain an inhibitor of complement mediated inhibition of immune precipitation (CMIP). This inhibitory effect can be produced by the addition of either purified monoclonal or polyclonal IgM rheumatoid factor (RF) to human serum. The specificity of the rheumatoid factor influences the degree of inhibition, and when precipitation ...
متن کاملIs IgG galactosylation the relevant factor for pregnancy-induced remission of rheumatoid arthritis?
During pregnancy, most patients with rheumatoid arthritis (RA) experience spontaneous improvement of their disease activity. Among the soluble candidates that have been investigated in search for the most relevant disease-remitting factor are the galactosylation levels of immunoglobulin G (IgG). In RA, a higher percentage of IgG lacking the terminal galactose residues, thought to play a pro-inf...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1979
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780220907